Bdkrb2 Gene Summary [Mouse]
Predicted to enable several functions, including G protein-coupled receptor binding activity; bradykinin receptor activity; and protein heterodimerization activity. Acts upstream of or within several processes, including negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; and vasodilation. Predicted to be located in Golgi apparatus and endosome. Predicted to be active in plasma membrane. Is expressed in metanephros; nervous system; and optic vesicle. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; hypertension; and rhinitis. Orthologous to human BDKRB2 (bradykinin receptor B2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bdkrb2 |
| Official Name | bradykinin receptor, beta 2 [Source:MGI Symbol;Acc:MGI:102845] |
| Ensembl ID | ENSMUSG00000021070 |
| Bio databases IDs | |
| Aliases | bradykinin receptor, beta 2 |
| Synonyms | B2, B(2), B2BKR, B2BRA, B2R, B2 receptor, BK-2, BK2R, Bkb2, BKR2, BRADYKININ B2 receptor, bradykinin receptor B2, bradykinin receptor, beta 2, bradykinin receptor, β 2, BRB2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bdkrb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- protease binding
- G-protein-coupled receptor binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- bradykinin receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Bdkrb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- cancer
- albuminuria
- neoplasia
- fibrosis
- shock response
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- diffuse mesangial sclerosis
- prostate cancer
role in cell
- migration
- apoptosis
- phosphorylation in
- proliferation
- production in
- chemotaxis
- activation in
- inhibition in
- formation
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- cytoplasmic aggregates
- membrane rafts
- cell membrane leading edge
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bdkrb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to salt stress
- G-protein coupled receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- blood circulation
- regulation of vascular permeability
- vasoconstriction
- cell surface receptor signaling pathway
- vasodilation
- elevation of cytosolic calcium ion concentration
- inflammatory response
- arachidonic acid secretion
- smooth muscle contraction
- negative regulation of peptidyl-serine phosphorylation
- regulation of vasoconstriction
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- type 1 angiotensin receptor binding
- protein heterodimerization activity
- bradykinin receptor activity
- protease binding