Cckbr Gene Summary [Mouse]
This gene encodes a multipass transmembrane receptor protein expressed in the central nervous system and gastrointestinal tract. Cholecystokinin and gastrin bind to the encoded protein to stimulate gastric acid secretion and mucosal growth in the gastrointestinal tract, and anxiety, pain sensation and memory in the brain. Mice lacking the encoded protein exhibit an increase in the basal gastric pH and gastrin levels in the bloodstream as well as mild hypocalcemia, secondary hyperparathyroidism and increased bone resorption. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Cckbr |
| Official Name | cholecystokinin B receptor [Source:MGI Symbol;Acc:MGI:99479] |
| Ensembl ID | ENSMUSG00000030898 |
| Bio databases IDs | |
| Aliases | cholecystokinin B receptor |
| Synonyms | CCK-2R, CCK2 receptor, CCK-B, CCKR-2, cholecystokinin B receptor, Cholrec, GASR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cckbr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- phosphatidylinositol 3-kinase regulator
- intracellular loop
- ligand-binding domain
- cholecystokinin receptor
- G-protein-coupled receptor binding
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- gastrin receptor
Pathways
Biological processes and signaling networks where the Cckbr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- major depression
- non-small cell lung cancer
- neoplasia
- obesity
- Huntington disease
- pancreatic neoplasia
- cancer
- non-small cell lung carcinoma
- pancreatic adenocarcinoma
role in cell
- quantity
- adhesion
- expression in
- growth
- proliferation
- phosphorylation in
- hypertrophy
- migration
- differentiation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- cell surface
- intracellular space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cckbr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- gastric acid secretion
- digestive tract development
- positive regulation of cell proliferation
- cell surface receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
- gland development
- pH reduction
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- gastrin receptor activity
- peptide hormone binding
- 1-phosphatidylinositol-3-kinase regulator activity
- cholecystokinin receptor activity
- type B gastrin/cholecystokinin receptor binding