JAK/Stat Signaling
The Janus Kinase (JAK)/Signal transducers and activators of transcription (STAT) pathway is the principal signaling mechanism for a wide array of cytokines and growth factors resulting in cell proliferation, differentiation, cell migration and apoptosis. A diverse array of ligands (e.g. cytokines, interferons, growth factors) and their receptors stimulate the JAK/STATpathway....
Pathway Summary
The Janus Kinase (JAK)/Signal transducers and activators of transcription (STAT) pathway is the principal signaling mechanism for a wide array of cytokines and growth factors resulting in cell proliferation, differentiation, cell migration and apoptosis. A diverse array of ligands (e.g. cytokines, interferons, growth factors) and their receptors stimulate the JAK/STATpathway.Intracellular activation occurs when ligand binding induces the dimerization of receptor subunits. Ligand-mediated receptor dimerization leads to JAK activation by transphosphorylation of proximal JAK units. The activated JAKs subsequently phosphorylate other targets, including the receptors and the STATs, which are the main substrates. The STATs are transcription factors that reside in the cytoplasm until activated. The tyrosine residue near the C terminus of STAT is phosphorylated by JAK. This results in dimerization of STAT and translocation to the nucleus. Once in the nucleus, dimerized STATs activate or repress transcription of target genes. Thus the JAK/STAT cascade provides a mechanism to translate an extracellular signal into a transcriptional response.The JAK/STAT signaling pathway interacts with other signaling pathways like the receptor tyrosine kinase (RTK)/RAS/mitogen-activated protein kinase (MAPK) pathway. Activated JAKs can phosphorylate their associated receptors that can serve as docking sites for SH2-containing adaptor proteins like SHP-2 and SHC. These in turn recruit the GRB2 adaptor and stimulate the Ras cascade. These signaling pathways mutually activate one another- the JAK activated RTK-RAS pathway triggers MAPK which inturn activates STATs. Other cascades like the phosphoinositide 3-kinase (PI3K) pathway are also activated by JAK and interact with the JAK/STAT pathway. In addition to activators of the JAK/STAT pathway there are also negative regulators. These include the suppressors of cytokine signaling (SOCS), protein inhibitors of activated STATs (PIAS) and protein tyrosine phosphatases (PTP).This pathway highlights the important components of JAK/STAT signaling.
JAK/Stat Signaling Genes list
Explore Genes related to JAK/Stat Signaling
AKT1AKT serine/threonine kinase 1 AKT2AKT serine/threonine kinase 2 AKT3AKT serine/threonine kinase 3 BCL2L1BCL2 like 1 CCKBRcholecystokinin B receptor CDKN1Acyclin dependent kinase inhibitor 1A CEBPBCCAAT enhancer binding protein beta CISHcytokine inducible SH2 containing protein ERASES cell expressed Ras FOSFos proto-oncogene, AP-1 transcription factor subunit GASTgastrin GNAQG protein subunit alpha q GRB2growth factor receptor bound protein 2 HRASHRas proto-oncogene, GTPase IL6interleukin 6 JAK1Janus kinase 1 JAK2Janus kinase 2 JAK3Janus kinase 3 JUNJun proto-oncogene, AP-1 transcription factor subunit KRASKRAS proto-oncogene, GTPase MAP2K1mitogen-activated protein kinase kinase 1 MAP2K2mitogen-activated protein kinase kinase 2 MAPK1mitogen-activated protein kinase 1 MAPK14mitogen-activated protein kinase 14 MAPK3mitogen-activated protein kinase 3 MRASmuscle RAS oncogene homolog MTORmechanistic target of rapamycin kinase NFKB1nuclear factor kappa B subunit 1 NFKB2nuclear factor kappa B subunit 2 NRASNRAS proto-oncogene, GTPase PIAS1protein inhibitor of activated STAT 1 PIAS2protein inhibitor of activated STAT 2 PIAS3protein inhibitor of activated STAT 3 PIAS4protein inhibitor of activated STAT 4 PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha PIK3C2Bphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta PIK3C2Gphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma PIK3C3phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3CAphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PIK3CBphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta PIK3CGphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma PIK3R1phosphoinositide-3-kinase regulatory subunit 1 PIK3R2phosphoinositide-3-kinase regulatory subunit 2 PIK3R3phosphoinositide-3-kinase regulatory subunit 3 PIK3R4phosphoinositide-3-kinase regulatory subunit 4 PIK3R5phosphoinositide-3-kinase regulatory subunit 5 PIK3R6phosphoinositide-3-kinase regulatory subunit 6 PTPN1protein tyrosine phosphatase non-receptor type 1 PTPN11protein tyrosine phosphatase non-receptor type 11 PTPN6protein tyrosine phosphatase non-receptor type 6 RAF1Raf-1 proto-oncogene, serine/threonine kinase RALARAS like proto-oncogene A RALBRAS like proto-oncogene B RAP1ARAP1A, member of RAS oncogene family RAP1BRAP1B, member of RAS oncogene family RAP2ARAP2A, member of RAS oncogene family RAP2BRAP2B, member of RAS oncogene family RASD1ras related dexamethasone induced 1 RASD2RASD family member 2 RELREL proto-oncogene, NF-kB subunit RELARELA proto-oncogene, NF-kB subunit RELBRELB proto-oncogene, NF-kB subunit RRASRAS related RRAS2RAS related 2 SHC1SHC adaptor protein 1 SOCS1suppressor of cytokine signaling 1 SOCS2suppressor of cytokine signaling 2 SOCS3suppressor of cytokine signaling 3 SOCS4suppressor of cytokine signaling 4 SOCS5suppressor of cytokine signaling 5 SOCS6suppressor of cytokine signaling 6 SOCS7suppressor of cytokine signaling 7 SOS1SOS Ras/Rac guanine nucleotide exchange factor 1 SOS2SOS Ras/Rho guanine nucleotide exchange factor 2 STAT1signal transducer and activator of transcription 1 STAT2signal transducer and activator of transcription 2 STAT3signal transducer and activator of transcription 3 STAT4signal transducer and activator of transcription 4 STAT5Asignal transducer and activator of transcription 5A STAT5Bsignal transducer and activator of transcription 5B STAT6signal transducer and activator of transcription 6 TYK2tyrosine kinase 2
Products related to JAK/Stat Signaling
Explore products related to JAK/Stat Signaling
GeneGlobe ID: UPHS-039Z | Cat. No.: 249955 | QuantiNova LNA Probe PCR Focus Panels
QuantiNova LNA Probe PCR Focus Panel Human JAK / STAT Signaling Pathway
QuantiNova LNA Probe PCR Focus Panel
GeneGlobe ID: SBHS-039Z | Cat. No.: 249950 | QuantiNova LNA PCR Focus Panels
QuantiNova LNA PCR Focus Panel Human JAK / STAT Signaling Pathway
QuantiNova LNA PCR Focus Panel
GeneGlobe ID: PAHS-039Z | Cat. No.: 330231 | RT2 Profiler PCR Arrays
RT² Profiler™ PCR Array Human JAK / STAT Signaling Pathway
RT2 Profiler PCR Array