D7Ertd443e Gene Summary [Mouse]
Enables histone deacetylase binding activity and ubiquitin protein ligase activity. Involved in several processes, including mitotic G2 DNA damage checkpoint signaling; protein stabilization; and response to ionizing radiation. Predicted to be located in actin cytoskeleton; cytoplasm; and plasma membrane. Predicted to be active in centriole; centrosome; and cytosol. Orthologous to human C10orf90 (chromosome 10 open reading frame 90). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | D7Ertd443e |
| Official Name | DNA segment, Chr 7, ERATO Doi 443, expressed [Source:MGI Symbol;Acc:MGI:1196431] |
| Ensembl ID | ENSMUSG00000030994 |
| Bio databases IDs | |
| Aliases | DNA segment, Chr 7, ERATO Doi 443, expressed |
| Synonyms | 4933400E14Rik, bA422P15.2, C1h10orf90, chromosome 10 open reading frame 90, D7Ertd443e, DNA segment, Chr 7, ERATO Doi 443, expressed, FATS, Gm497, LOC103695050, similar to human chromosome 10 open reading frame 90 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse D7ertd443e often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centrosomal C10orf90
- ubiquitin protein ligase activity
- ALMS motif
- histone deacetylase binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute myeloid leukemia
- myopia
- skin wound
- spontaneous preterm birth
- ankylosing spondylitis
- age-related hearing loss
regulated by
- IFNGR1
- tetradecanoylphorbol acetate
- Gstp1 (includes others)
- imiquimod
role in cell
- growth
- DNA damage response
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse D7ertd443e gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- regulation of centriole replication
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriole
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- microtubule binding