C10orf90 Gene Summary [Human]
Predicted to enable histone deacetylase binding activity; microtubule binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein stabilization; regulation of cell cycle process; and response to ionizing radiation. Located in several cellular components, including cytoskeleton; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | C10orf90 |
| Official Name | chromosome 10 open reading frame 90 [Source:HGNC Symbol;Acc:HGNC:26563] |
| Ensembl ID | ENSG00000154493 |
| Bio databases IDs | |
| Aliases | chromosome 10 open reading frame 90, fragile-site associated tumor suppressor |
| Synonyms | 4933400E14Rik, bA422P15.2, C1h10orf90, chromosome 10 open reading frame 90, D7Ertd443e, DNA segment, Chr 7, ERATO Doi 443, expressed, FATS, Gm497, LOC103695050, similar to human chromosome 10 open reading frame 90 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human C10orf90 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Centrosomal C10orf90
- ubiquitin protein ligase activity
- ALMS motif
- histone deacetylase binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- acute myeloid leukemia
- myopia
- skin wound
- spontaneous preterm birth
- ankylosing spondylitis
- age-related hearing loss
regulated by
- IFNGR1
- tetradecanoylphorbol acetate
- Gstp1 (includes others)
- imiquimod
role in cell
- growth
- DNA damage response
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human C10orf90 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- regulation of centriole replication
- protein stabilization
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- centriole
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- microtubule binding