Trim66 Gene Summary [Mouse]
Enables chromatin binding activity and identical protein binding activity. Acts upstream of or within negative regulation of DNA-templated transcription. Located in chromocenter and nucleus. Is expressed in olfactory epithelium. Orthologous to human TRIM66 (tripartite motif containing 66). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim66 |
| Official Name | tripartite motif-containing 66 [Source:MGI Symbol;Acc:MGI:2152406] |
| Ensembl ID | ENSMUSG00000031026 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 66 |
| Synonyms | C11ORF29, KIAA0298, Kiaa0298-hp, LOC256273, TIF1D, TIF1DELTA, tripartite motif-containing 66 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim66 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- PHD zinc finger
- transcription regulator
- B-Box C-terminal domain
- chromatin binding
- protein binding
- Bromodomain
- identical protein binding
- B-box-type zinc finger superfamily
- UV excision repair protein Rad23
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- PHD finger superfamily
- B-box zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- obesity
- metabolic syndrome X
- infection by HIV-1
role in cell
- activation in
- expression in
- homologous recombination repair in
- innate immune response in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- granules
- chromosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim66 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- zinc ion binding