Trmt2a Gene Summary [Mouse]
Predicted to enable C-methyltransferase activity and tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent. Predicted to be involved in mRNA processing; methylation; and tRNA processing. Predicted to be located in cytosol. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; gut; and sensory organ. Orthologous to human TRMT2A (tRNA methyltransferase 2 homolog A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Trmt2a |
| Official Name | TRM2 tRNA methyltransferase 2A [Source:MGI Symbol;Acc:MGI:96270] |
| Ensembl ID | ENSMUSG00000022721 |
| Bio databases IDs | |
| Aliases | TRM2 tRNA methyltransferase 2A |
| Synonyms | HTF9C, TRM2 tRNA methyltransferase 2A, tRNA methyltransferase 2 homolog A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trmt2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- RNA recognition motif (RRM) superfamily
- S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase
- RNA recognition motif
- 23S rRNA (uracil-5-)-methyltransferase RumA
- protein binding
- C-methyltransferase
- methyltransferase domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trmt2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA processing
- mRNA processing
- methylation
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- C-methyltransferase activity
- S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity