Sec16a Gene Summary [Mouse]
Involved in endoplasmic reticulum organization; protein exit from endoplasmic reticulum; and protein localization to plasma membrane. Located in endoplasmic reticulum exit site and perinuclear region of cytoplasm. Is expressed in cerebral cortex. Orthologous to human SEC16A (SEC16 homolog A, endoplasmic reticulum export factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sec16a |
| Official Name | SEC16 homolog A, endoplasmic reticulum export factor [Source:MGI Symbol;Acc:MGI:2139207] |
| Ensembl ID | ENSMUSG00000026924 |
| Bio databases IDs | |
| Aliases | SEC16 homolog A, endoplasmic reticulum export factor |
| Synonyms | AU024582, C230052J16Rik, KIAA0310, MGC38812, p250, SEC16, SEC16 homolog A, endoplasmic reticulum export factor, SEC16L |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec16a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
- protein binding
- Vesicle coat trafficking protein Sec16 mid-region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- inflammatory bowel disease
- COVID-19
- skin squamous cell carcinoma
- squamous cell skin cancer
- squamous-cell carcinoma
- squamous cell cancer
- epithelial basal cell carcinoma
role in cell
- organization
- osteogenesis by
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec16a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi organization
- Golgi to plasma membrane transport
- endoplasmic reticulum organization
- substantia nigra development
- COPII vesicle coating
- regulation of COPII vesicle coating
- ER to Golgi vesicle-mediated transport
- protein exit from endoplasmic reticulum
- autophagy
- protein localization to endoplasmic reticulum exit site
- protein stabilization
- response to endoplasmic reticulum stress
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- ER to Golgi transport vesicle membrane
- cytosol
- endoplasmic reticulum exit site
- Golgi membrane
- organelle membrane
Molecular Function
What the gene product does at the molecular level
- protein binding