Fundc2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Involved in regulation of platelet activation. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Orthologous to human FUNDC2 (FUN14 domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fundc2 |
| Official Name | FUN14 domain containing 2 [Source:MGI Symbol;Acc:MGI:1914641] |
| Ensembl ID | ENSMUSG00000031198 |
| Bio databases IDs | |
| Aliases | FUN14 domain containing 2 |
| Synonyms | 4833415N24Rik, DC44, FUN14 domain containing 2, HCBP6, HCC3, PD03104 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fundc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3,4,5-triphosphate binding
- FUN14 family
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- thrombocytopenia
- epithelial cancer
- liver neoplasia
- hepatocellular carcinoma
- liver cancer
- venous thromboembolism
- severe hemophilia A and moyamoya syndrome
- organismal death
- cardiac fibrosis
role in cell
- apoptosis
- activation
- mitochondrial respiration in
- elongation
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fundc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular triglyceride homeostasis
- mitochondrion degradation
- regulation of platelet activation
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding