Naca Gene Summary [Mouse]
Enables TBP-class protein binding activity and transcription coactivator activity. Acts upstream of or within myoblast migration. Located in cytoplasm and nucleus. Is expressed in several structures, including aorta; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human NACA (nascent polypeptide associated complex subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Naca |
| Official Name | nascent polypeptide-associated complex alpha polypeptide [Source:MGI Symbol;Acc:MGI:106095] |
| Ensembl ID | ENSMUSG00000061315 |
| Bio databases IDs | |
| Aliases | nascent polypeptide-associated complex alpha polypeptide |
| Synonyms | alpha-NAC, Gm1878, HSD48, mKIAA0363, NACA1, NAC-alpha, NACAM, NAC-α, Nascent polypeptide associated complex alpha chain, Nascent polypeptide-associated complex alpha polypeptide, nascent polypeptide associated complex subunit alpha, nascent polypeptide associated complex subunit α, Nascent polypeptide associated complex α chain, Nascent polypeptide-associated complex α polypeptide, skNAC, α-NAC |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Naca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- alpha-NAC-related protein
- transcription regulator
- transcription co-activator
- pxlxp motif
- protein binding
- TATA-binding protein binding
- HYPK UBA domain
- NAC domain
Pathways
Biological processes and signaling networks where the Naca gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pancreatic carcinoma
- suicide attempt
- pancreatic epithelial cancer
- primary antiphospholipid antibody syndrome
- arrhythmia
role in cell
- expression in
- quantity
- migration
- proliferation
- differentiation
- cell proliferation
- mineralization by
- stabilization in
- translation in
- metastatic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Naca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart trabecula morphogenesis
- protein transport
- positive regulation of skeletal muscle tissue growth
- cardiac ventricle development
- positive regulation of transcription from RNA polymerase II promoter
- protein targeting to membrane
- translation
- skeletal muscle tissue regeneration
- negative regulation of transcription from RNA polymerase II promoter
- wound healing
- regulation of skeletal muscle fiber development
- positive regulation of cell proliferation involved in heart morphogenesis
- negative regulation of striated muscle cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- nascent polypeptide-associated complex
- extracellular vesicular exosome
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription coactivator activity
- unfolded protein binding