Phka2 Gene Summary [Mouse]
Predicted to enable calmodulin binding activity. Predicted to be involved in glycogen metabolic process. Predicted to be located in plasma membrane. Predicted to be part of phosphorylase kinase complex. Is expressed in several structures, including adipose tissue; cardiovascular system; exocrine gland; female reproductive system; and respiratory system. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease IXa. Orthologous to human PHKA2 (phosphorylase kinase regulatory subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Phka2 |
| Official Name | phosphorylase kinase alpha 2 [Source:MGI Symbol;Acc:MGI:97577] |
| Ensembl ID | ENSMUSG00000031295 |
| Bio databases IDs | |
| Aliases | phosphorylase kinase alpha 2 |
| Synonyms | 6330505C01Rik, D330034O08, GSD9A, Hepatic phk, LOC678835, PHK, phosphorylase kinase alpha 2, phosphorylase kinase regulatory subunit alpha 2, phosphorylase kinase regulatory subunit α 2, phosphorylase kinase α 2, PYK, PYKL, XLG, XLG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phka2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- kinase domain
- protein binding
- phosphorylase kinase
Pathways
Biological processes and signaling networks where the Phka2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glycogen storage disease type IXA
- hereditary disorder
- glycogen storage disease type IX
- androgenic alopecia
- gastric epithelial cancer
- hepatoid gastric adenocarcinoma
- Forsius-Eriksson type ocular albinism
regulates
- L-serine
- tyrosyl radical
- carbohydrate
role in cell
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phka2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- protein modification process
- generation of precursor metabolites and energy
- glycogen metabolic process
Cellular Component
Where in the cell the gene product is active
- phosphorylase kinase complex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphorylase kinase activity
- calmodulin binding
- protein binding