Ppp1r3c Gene Summary [Mouse]
Enables glycogen binding activity; molecular adaptor activity; and protein phosphatase binding activity. Involved in glycogen biosynthetic process. Acts upstream of or within glycogen metabolic process. Is active in cytosol. Is expressed in genitourinary system; liver; and nasal capsule. Used to study type 2 diabetes mellitus. Orthologous to human PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r3c |
| Official Name | protein phosphatase 1, regulatory subunit 3C [Source:MGI Symbol;Acc:MGI:1858229] |
| Ensembl ID | ENSMUSG00000067279 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 3C |
| Synonyms | LOC100910671, PPP1R5, Ppp1rc, protein PHOSPHATASE 1, Protein phosphatase 1 glycogen targeting subunit, protein phosphatase 1 regulatory subunit 3C, protein phosphatase 1, regulatory subunit 3C, PTG, R5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r3c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Starch/carbohydrate-binding module (family 53)
- Carbohydrate/starch-binding module (family 21)
- protein serine/threonine phosphatase
- protein phosphatase
- protein phosphatase binding
- phosphatase
- enzyme binding
- protein binding
- polysaccharide binding
- [phosphorylase] phosphatase
- PBD_PPP1R3
Pathways
Biological processes and signaling networks where the Ppp1r3c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- insulin resistance
- psoriasis
- acute myeloid leukemia
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- androgenic alopecia
- autosomal dominant polycystic kidney disease
regulates
- p38 MAPK
- PP1
- SLC2A1
- fatty acid
- triacylglycerol
- D-glucose
- glycogen
- glycogen synthase
- insulin
- ketone
role in cell
- dephosphorylation in
- formation
- quantity
- expression in
- activation in
- accumulation in
- abnormal morphology
- uptake by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r3c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycogen biosynthetic process
- glycogen metabolic process
- regulation of glycogen biosynthetic process
Cellular Component
Where in the cell the gene product is active
- protein phosphatase type 1 complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein phosphatase binding
- protein binding
- protein phosphatase 1 binding
- glycogen binding
- binding, bridging