G6pdx Gene Summary [Mouse]
Enables glucose-6-phosphate dehydrogenase activity and identical protein binding activity. Involved in pentose-phosphate shunt, oxidative branch. Acts upstream of or within several processes, including NADP biosynthetic process; erythrocyte development; and maintenance of blood vessel diameter homeostasis by renin-angiotensin. Is active in cytosol. Is expressed in several structures, including brain; genitourinary system; immune system; liver; and mammary gland. Used to study favism. Human ortholog(s) of this gene implicated in anemia (multiple); cerebrovascular disease; diabetes mellitus; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | G6pdx |
| Official Name | glucose-6-phosphate dehydrogenase X-linked [Source:MGI Symbol;Acc:MGI:105979] |
| Ensembl ID | ENSMUSG00000031400 |
| Bio databases IDs | |
| Aliases | glucose-6-phosphate dehydrogenase X-linked |
| Synonyms | CNSHA1, G28A, G6PD1, G6PDX, Glucose-6-P Dehydrogenase, Glucose-6-phosphate 1-dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase X-linked, Gpdx |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse G6pdx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glucose-6-phosphate dehydrogenase, C-terminal domain
- Glucose-6-phosphate dehydrogenase, NAD binding domain
- NADP binding
- glucose-6-phosphate 1-dehydrogenase
- protein homodimerization
- glucose binding
- enzyme
- protein binding
- carbohydrate binding
- identical protein binding
Pathways
Biological processes and signaling networks where the G6pdx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- hypertension
- anemia
- neoplasia
- nonspherocytic hemolytic anemia due to G6PD deficiency
- prostate cancer
- breast carcinoma
- hereditary disorder
- glucosephosphate dehydrogenase deficiency
- Alzheimer disease
role in cell
- proliferation
- expression in
- apoptosis
- phosphorylation in
- invasion by
- cell death
- production in
- binding in
- glycolysis in
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cell periphery
- Nucleus
- centrosome
- microtubule organizing centers
- cytosol
- cytoplasmic face of plasma membrane
- cytoplasmic droplets
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse G6pdx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to food
- response to iron(III) ion
- pentose-phosphate shunt, oxidative branch
- negative regulation of cell growth involved in cardiac muscle cell development
- pentose-phosphate shunt
- cholesterol biosynthetic process
- NADPH regeneration
- response to organic cyclic compound
- glucose metabolic process
- regulation of neuron apoptotic process
- substantia nigra development
- erythrocyte maturation
- response to ethanol
- glucose 6-phosphate metabolic process
- glutathione metabolic process
- lipid metabolic process
- NADP metabolic process
- pentose biosynthetic process
- cellular response to oxidative stress
- negative regulation of protein glutathionylation
- ribose phosphate biosynthetic process
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- centriolar satellite
- intracellular membrane-bounded organelle
- membrane
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- identical protein binding
- NADP binding
- protein binding
- protein homodimerization activity
- glucose-6-phosphate dehydrogenase activity