Idh1 Gene Summary [Mouse]
Enables isocitrate dehydrogenase (NADP+) activity. Involved in NADPH regeneration. Acts upstream of or within glutathione metabolic process; regulation of phospholipid metabolic process; and response to oxidative stress. Located in mitochondrion. Is active in cytosol and peroxisomal matrix. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in autoimmune disease; hematologic cancer (multiple); hepatocellular clear cell carcinoma; and high grade glioma (multiple). Orthologous to human IDH1 (isocitrate dehydrogenase (NADP(+)) 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Idh1 |
| Official Name | isocitrate dehydrogenase 1 (NADP+), soluble [Source:MGI Symbol;Acc:MGI:96413] |
| Ensembl ID | ENSMUSG00000025950 |
| Bio databases IDs | |
| Aliases | isocitrate dehydrogenase 1 (NADP+), soluble |
| Synonyms | E030024J03Rik, HEL-216, HEL-S-26, Id-1, IDCD, IDH, IDP, IDPC, ISOCITRATE DEHYDROGENASE, isocitrate dehydrogenase 1 (NADP+), soluble, isocitrate dehydrogenase (NADP(+)) 1, PICD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Idh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Isocitrate/isopropylmalate dehydrogenase
- NADP binding
- isocitrate dehydrogenase (NADP)
- protein homodimerization
- enzyme
- protein binding
- magnesium ion binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Idh1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- astrocytoma
- lower-risk myelodysplastic syndrome
- oligodendroglioma
- recurrent astrocytoma
- recurrent oligodendroglioma
- acute myeloid leukemia
- refractory anemia with excess of blasts type 2
- refractory acute myeloid leukemia
- WHO grade II astrocytoma
role in cell
- replication in
- phosphorylation in
- apoptosis
- cell death
- production in
- proliferation
- growth
- expression in
- cell viability
- generation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- organelle lumens
- Mitochondria
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Idh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- regulation of phospholipid catabolic process
- glyoxylate cycle
- glutathione metabolic process
- NADP metabolic process
- isocitrate metabolic process
- tricarboxylic acid cycle
- response to steroid hormone stimulus
- female gonad development
- regulation of phospholipid biosynthetic process
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- extracellular vesicular exosome
- cytoplasm
- mitochondrion
- cytosol
- secretory granule lumen
- peroxisomal matrix
- extracellular region
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- NADP binding
- identical protein binding
- protein homodimerization activity
- protein binding
- NAD binding
- cadherin binding
- isocitrate dehydrogenase (NADP+) activity