Adam3

Predicted to enable metalloendopeptidase activity. Involved in fertilization and flagellated sperm motility. Acts upstream of or within binding activity of sperm to zona pellucida; gene expression; and regulation of macromolecule metabolic process. Located in membrane raft; plasma membrane; and sperm head. Part of protein-containing complex. Is active in cell surface. Human ortholog(s) of this gene implicated in brain glioma and conjunctival squamous cell carcinoma. Orthologous to human ADAM3A (ADAM metallopeptidase domain 3A (pseudogene)). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adam3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Adam3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.