Cd9 Gene Summary [Mouse]
Enables integrin binding activity. Involved in several processes, including fusion of sperm to egg plasma membrane involved in single fertilization; myoblast fusion involved in skeletal muscle regeneration; and paranodal junction assembly. Acts upstream of or within negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular exosome. Is expressed in several structures, including alimentary system; heart; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in prostate adenocarcinoma. Orthologous to human CD9 (CD9 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd9 |
| Official Name | CD9 antigen [Source:MGI Symbol;Acc:MGI:88348] |
| Ensembl ID | ENSMUSG00000030342 |
| Bio databases IDs | |
| Aliases | CD9 antigen |
| Synonyms | BTCC-1, CD9 ANTIGEN, CD9 molecule, DRAP-27, MIC3, MRP-1, TSPAN-29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- palmitoylation site
- tetraspanin_LEL
- cytoplasmic domain
- integrin binding
- transmembrane domain
- extracellular loop
- protein binding
- Tetraspanin family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- breast cancer
- gastric adenocarcinoma
- renal cell carcinoma
- renal cell cancer
- organismal death
- renal cancer
- metastasis
- systemic lupus erythematosus
- gastric epithelial cancer
role in cell
- proliferation
- expression in
- apoptosis
- cell viability
- cell death
- outgrowth
- chemotaxis
- migration
- calcium response
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- detergent resistant lipid raft fraction
- tetraspanin-enriched microdomain
- endocytic vesicle membrane
- intracellular structures
- Cytoplasm
- cell surface
- cell borders
- Extracellular Space
- cell periphery
- intracellular space
- microvesicles
- membrane surface
- cellular membrane
- Nucleus
- intercellular junctions
- cell-cell contacts
- basal cell surfaces
- membrane ruffles
- plasma membrane extracellular face
- microdomains
- apical membrane
- uropod
- basolateral membrane
- endosomal compartment
- alpha granules
- myelin sheath
- secretory granules
- membrane rafts
- microvilli
- filopodia
- exosomes
- basement membrane
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- sperm-egg recognition
- negative regulation of cell proliferation
- negative regulation of platelet aggregation
- cell adhesion
- fusion of sperm to egg plasma membrane
- glial cell migration
- paranodal junction assembly
- myoblast fusion involved in skeletal muscle regeneration
- platelet activation
- receptor internalization
- cellular response to low-density lipoprotein particle stimulus
Cellular Component
Where in the cell the gene product is active
- extracellular space
- platelet alpha granule membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- focal adhesion
- membrane
- external side of plasma membrane
- macromolecular complex
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- integrin binding