Gpt2 Gene Summary [Mouse]
Predicted to enable L-alanine:2-oxoglutarate aminotransferase activity. Predicted to be involved in 2-oxoglutarate metabolic process; L-alanine metabolic process; and gluconeogenesis. Located in mitochondrion. Is expressed in several structures, including alimentary system; musculature; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with spastic paraplegia and microcephaly. Orthologous to human GPT2 (glutamic--pyruvic transaminase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpt2 |
| Official Name | glutamic pyruvate transaminase (alanine aminotransferase) 2 [Source:MGI Symbol;Acc:MGI:1915391] |
| Ensembl ID | ENSMUSG00000031700 |
| Bio databases IDs | |
| Aliases | glutamic pyruvate transaminase (alanine aminotransferase) 2 |
| Synonyms | 4631422C05RIK, ALT2, Cc2-5, glutamic pyruvate transaminase (alanine aminotransferase) 2, glutamic--pyruvic transaminase 2, LOC100909925, MRT49, NEDSPM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- tyrosine aminotransferase, eukaryotic
- AAT_I
- enzyme
- Aminotransferase class I and II
- alanine transaminase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- neoplasia
- colorectal cancer
- metastasis
- epithelial cancer
- hereditary disorder
- neurodevelopmental disorder with spastic paraplegia and microcephaly
- autosomal dominant spastic paraplegia type 73
- liver cancer
- non-small cell lung cancer
role in cell
- proliferation
- expression in
- production in
- cell death
- growth
- phosphorylation in
- cell viability
- number
- migration
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Nucleus
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- biosynthetic process
- L-alanine metabolic process
- L-alanine catabolic process
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- L-alanine:2-oxoglutarate aminotransferase activity