Epha6 Gene Summary [Mouse]
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in nucleoplasm. Predicted to be active in dendrite and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; endometrium; male reproductive gland or organ; and sensory organ. Orthologous to human EPHA6 (EPH receptor A6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Epha6 |
| Official Name | Eph receptor A6 [Source:MGI Symbol;Acc:MGI:108034] |
| Ensembl ID | ENSMUSG00000055540 |
| Bio databases IDs | |
| Aliases | Eph receptor A6 |
| Synonyms | AABR07033882.1, DKFZP434C1418, EHK-2, EK12, EPA6, EPH receptor A6, HEK12, LOC203806, m-ehk2, PRO57066 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Epha6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ligand Binding Domain of Ephrin Receptors
- Protein kinase (unclassified specificity)
- Tyrosine-protein kinase ephrin type A/B receptor-like
- Protein tyrosine and serine/threonine kinase
- SAM (Sterile alpha motif )
- Purple acid Phosphatase, N-terminal domain
- protein binding
- Fibronectin type 3 domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Sterile alpha motif
- Protein Kinases, catalytic domain
- Transmembrane domain of Ephrin Receptor A1 Protein Tyrosine Kinase
- FN3
- SAM domain (Sterile alpha motif)
- Tyrosine kinase, catalytic domain
- Ephrin receptor ligand binding domain
Pathways
Biological processes and signaling networks where the Epha6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- cutaneous melanoma cancer
- advanced non-small cell lung cancer
- advanced non-small cell lung adenocarcinoma
- stage IV lung squamous cell carcinoma
- non-squamous lung carcinoma
- metastatic non-small cell lung cancer
- advanced large cell lung carcinoma
- metastatic large cell lung carcinoma
- locally advanced non-small cell lung cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Epha6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ephrin receptor signaling pathway
- axon guidance
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- transmembrane-ephrin receptor activity