Cotl1 Gene Summary [Mouse]
Enables actin binding activity and enzyme binding activity. Involved in defense response to fungus. Predicted to be located in cytosol. Predicted to be active in cortical actin cytoskeleton and site of polarized growth. Predicted to colocalize with actin filament. Is expressed in several structures, including brain; gut; renal cortex; sensory organ; and trachea. Orthologous to human COTL1 (coactosin like F-actin binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cotl1 |
| Official Name | coactosin-like 1 (Dictyostelium) [Source:MGI Symbol;Acc:MGI:1919292] |
| Ensembl ID | ENSMUSG00000031827 |
| Bio databases IDs | |
| Aliases | coactosin-like 1 (Dictyostelium) |
| Synonyms | 1810074P22Rik, 2010004C08Rik, CLP, coactosin-like F-actin binding protein 1, Coactosin-like Rho GDP-Dissociation Inhibitor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cotl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cofilin/tropomyosin-type actin-binding protein
- Actin depolymerization factor/cofilin- and gelsolin-like domains
- actin binding
- enzyme binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- squamous-cell carcinoma
- squamous cell cancer
- androgenic alopecia
- autoimmune pancreatitis
- maculopapular rash
- epilepsy
role in cell
- formation in
- growth
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- insoluble fractions
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- cytosol
- growth cone
- actin stress fibers
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cotl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of actin filament polymerization
- defense response to fungus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- site of polarized growth
- cytosol
- secretory granule lumen
- actin filament
- extracellular region
- cortical actin cytoskeleton
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding
- actin binding
- enzyme binding