Cyb5b Gene Summary [Mouse]
Predicted to enable enzyme activator activity and heme binding activity. Predicted to contribute to nitrite reductase (NO-forming) activity. Predicted to be involved in nitric oxide biosynthetic process. Located in mitochondrial inner membrane. Is expressed in several structures, including adrenal gland; craniocervical region bone; gut; neural retina; and urinary system. Orthologous to human CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb5b |
| Official Name | cytochrome b5 type B [Source:MGI Symbol;Acc:MGI:1913677] |
| Ensembl ID | ENSMUSG00000031924 |
| Bio databases IDs | |
| Aliases | cytochrome b5 type B |
| Synonyms | 1810044O22Rik, CYB5-M, CYPB5M, cytochrome b5 type B, Mt-Cytb5, OMB5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyb5b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nitrite reductase
- ubiquinol-cytochrome-c reductase
- Cytochrome b5-like Heme/Steroid binding domain
- enzyme
- protein binding
- heme binding
- enzyme activator activity
Pathways
Biological processes and signaling networks where the Cyb5b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- preeclampsia
- infection by Hepatitis C virus genotype 2
role in cell
- autophagy
- autophagy in
- reduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- mitochondrial fraction
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyb5b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- xenobiotic metabolic process
- nitric oxide biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
- membrane
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- nitrite reductase (NO-forming) activity
- metal ion binding
- enzyme activator activity
- heme binding