Acad8 Gene Summary [Mouse]
Predicted to enable flavin adenine dinucleotide binding activity and short-chain 2-methyl fatty acyl-CoA dehydrogenase activity. Predicted to be involved in lipid metabolic process and valine catabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ACAD8 (acyl-CoA dehydrogenase family member 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Acad8 |
| Official Name | acyl-Coenzyme A dehydrogenase family, member 8 [Source:MGI Symbol;Acc:MGI:1914198] |
| Ensembl ID | ENSMUSG00000031969 |
| Bio databases IDs | |
| Aliases | acyl-Coenzyme A dehydrogenase family, member 8 |
| Synonyms | 2310016C19Rik, acyl-CoA dehydrogenase family member 8, acyl-CoA dehydrogenase family, member 8, acyl-Coenzyme A dehydrogenase family, member 8, ARC42, IBDH, RGD1564209 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acad8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Acyl-CoA dehydrogenase, C-terminal domain
- acyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, middle domain
- enzyme
- protein binding
- 2-methylacyl-CoA dehydrogenase
- Acyl-CoA dehydrogenase, N-terminal domain
Pathways
Biological processes and signaling networks where the Acad8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- hereditary disorder
- liver cancer
- epithelial cancer
- isobutyryl-CoA dehydrogenase deficiency
- lung adenocarcinoma formation
- lung adenocarcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acad8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lipid metabolic process
- valine catabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- acyl-CoA dehydrogenase activity
- flavin adenine dinucleotide binding