Srgap3 Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Used to study schizophrenia. Orthologous to human SRGAP3 (SLIT-ROBO Rho GTPase activating protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Srgap3 |
| Official Name | SLIT-ROBO Rho GTPase activating protein 3 [Source:MGI Symbol;Acc:MGI:2152938] |
| Ensembl ID | ENSMUSG00000030257 |
| Bio databases IDs | |
| Aliases | SLIT-ROBO Rho GTPase activating protein 3 |
| Synonyms | ARHGAP14, D130026O08RIK, Gbi, MEGAP, mKIAA0411, RGD1563152, SLIT-ROBO Rho GTPase activating protein 3, SRGAP2, WRP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Srgap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Fes/CIP4, and EFC/F-BAR homology domain
- GTPase activator
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Srgap3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cerebral edema
- idiopathic pulmonary fibrosis
- generalized dystonia
- late-onset Alzheimer disease
- hydrocephalus
- 3p- syndrome
- motor dysfunction or movement disorder
- tic disorder
- Moyamoya disease
role in cell
- outgrowth
- formation
- abnormal morphology
- formation in
- enlargement
- enlargement in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- cytosol
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Srgap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of small GTPase mediated signal transduction
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity