Cd300lf Gene Summary [Mouse]
Enables several functions, including interleukin-4 receptor binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in several processes, including interleukin-13-mediated signaling pathway; positive regulation of interleukin-4-mediated signaling pathway; and regulation of apoptotic cell clearance. Acts upstream of or within osteoclast differentiation. Predicted to be active in plasma membrane. Is expressed in early conceptus; embryo; and retina. Orthologous to human CD300LF (CD300 molecule like family member f). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Cd300lf |
| Official Name | CD300 molecule like family member F [Source:MGI Symbol;Acc:MGI:2442359] |
| Ensembl ID | ENSMUSG00000047798 |
| Bio databases IDs | |
| Aliases | CD300 molecule like family member F |
| Synonyms | CD300f, CD300 molecule like family member F, CLIM1, CLM-1, Digr2, F730004D16Rik, IgSF13, IREM-1, LMIR3, NKIR, Pigr3, RGD1309733 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd300lf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid binding
- SHP2-interacting transmembrane adaptor protein, SIT
- extracellular domain
- sphingolipid binding
- viral receptor
- interleukin-4 receptor binding
- immunoglobulin domain
- protein binding
- identical protein binding
- binding protein
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- Immunoglobulin like
- cytosolic tail domain
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- experimentally induced airway hyperresponsiveness
- coronary artery disease
- anhedonia
- hypersensitivity reaction type I
- demyelination
- passive cutaneous anaphylaxis
- dermatitis
- infection by Murine norovirus
role in cell
- production in
- expression in
- activation in
- activity
- function
- activation
- synthesis in
- phosphorylation in
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- apical cell surfaces
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd300lf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- interleukin-13-mediated signaling pathway
- positive regulation of apoptotic cell clearance
- negative regulation of apoptotic cell clearance
- negative regulation of mast cell activation
- negative regulation of MyD88-dependent toll-like receptor signaling pathway
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ceramide binding
- phosphatidylserine binding
- identical protein binding
- protein binding
- transmembrane signaling receptor activity
- interleukin-4 receptor binding