Abcb10 Gene Summary [Mouse]
This gene encodes a member of the ATP-binding cassette superfamily of transporters. ATP-binding cassette proteins transport various molecules across extra- and intra-cellular membranes. The encoded protein is localized to the mitochondrial inner membrane where it interacts with and stabilizes mitoferrin-1, and is important for heme biosynthesis. Additional evidence suggests the encoded protein is involved in oxidative stress protection and erythropoisesis. [provided by RefSeq, May 2013]
Details
| Type | Protein Coding |
| Official Symbol | Abcb10 |
| Official Name | ATP-binding cassette, sub-family B (MDR/TAP), member 10 [Source:MGI Symbol;Acc:MGI:1860508] |
| Ensembl ID | ENSMUSG00000031974 |
| Bio databases IDs | |
| Aliases | ATP-binding cassette, sub-family B (MDR/TAP), member 10 |
| Synonyms | Abcb12, Abc-me, ATP binding cassette subfamily B member 10, ATP-binding cassette, sub-family B member 10, EST20237, M-ABC2, MDR1, MTABC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Abcb10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- P-loop containing region of AAA domain
- type I secretion system ABC transporter, PrtD family
- ATP binding
- Conjugate Transporter-2 (CT2) Family protein
- identical protein binding
- ATPase
- heme ABC exporter, ATP-binding protein CcmA
- nucleotide-binding domain
- thiol reductant ABC exporter, CydC subunit
- energy-coupling factor transporter ATPase
- nickel import ATP-binding protein NikE
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
- ATPase activity, coupled to transmembrane movement of substances
- lipid A export permease/ATP-binding protein MsbA
- glucan exporter ATP-binding protein
- protein binding
- urea ABC transporter, ATP-binding protein UrtE
- ABC transporter transmembrane region
- Six-transmembrane helical domain of the ATP-binding cassette transporters
- thiol reductant ABC exporter, CydD subunit
- NHLM bacteriocin system ABC transporter, ATP-binding protein
- protein homodimerization
- ABC transporter
- ABC transporter, permease/ATP-binding protein
- transporter
Pathways
Biological processes and signaling networks where the Abcb10 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- glioma formation
- non-small cell lung cancer
- diabetic retinopathy
- primary biliary cirrhosis
- non-small cell lung carcinoma
- glioma
- diabetes mellitus
regulated by
- fibroblasts
- beta-estradiol
- CP-724,714
- pinometostat
- bexarotene
- cisplatin
- rifampin
- lipopolysaccharide
- MYC
- trichostatin A
role in cell
- expression in
- phosphorylation in
- proliferation
- differentiation
- synthesis in
- uptake in
- number
- abnormal morphology
- development
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- inner surface
- Plasma Membrane
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Abcb10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transmembrane transport
- mitochondrial transport
- positive regulation of hemoglobin biosynthetic process
- heme biosynthetic process
- erythrocyte development
- positive regulation of heme biosynthetic process
- positive regulation of erythrocyte differentiation
- mitochondrial unfolded protein response
Cellular Component
Where in the cell the gene product is active
- mitochondrial membrane
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein homodimerization activity
- protein binding