Krt14 Gene Summary [Mouse]

This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Details

Type
Processed Transcript
Official Symbol
Krt14
Official Name
keratin 14 [Source:MGI Symbol;Acc:MGI:96688]
Ensembl ID
ENSMUSG00000045545
Bio databases IDs NCBI: 16664 Ensembl: ENSMUSG00000045545
Aliases keratin 14
Synonyms 50KDA type I EPIDERMAL KERATIN, CK-14, Cytokeratin 14, EBS1, EBS1A, EBS1B, EBS1C, EBS1D, EBS3, EBS4, K14, Keratin 1-14, keratin 14, Krt-1.14, KRT1-14, NFJ
Species
Mouse, Mus musculus
OrthologiesHuman

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • intermediate filament binding
  • structural constituent of cytoskeleton
  • protein binding
  • Intermediate filament protein

Pathways

Biological processes and signaling networks where the Krt14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • blistering
  • neoplasia
  • metastasis
  • epithelial cancer
  • breast cancer
  • aortic valve calcification
  • localized epidermolysis bullosa simplex 1C
  • dermatopathia pigmentosa reticularis
  • eczema
  • epidermolysis bullosa simplex
regulated by
role in cell
  • expression in
  • differentiation
  • proliferation
  • phosphorylation in
  • apoptosis
  • activation in
  • formation
  • cell cycle progression
  • invasion by
  • upregulation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • detergent-insoluble fractions
  • pH resistant lipid raft fraction
  • detergent resistant lipid raft fraction
  • cornified envelope
  • cytoskeleton
  • cell periphery
  • intracellular space
  • basal compartment
  • Nucleus
  • intermediate filaments
  • cytosol
  • keratin intermediate filaments
  • apical processes
  • cytoskeletal fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt14 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • epithelial cell differentiation
  • keratinocyte differentiation
  • stem cell differentiation
  • intermediate filament bundle assembly
  • epidermis development
  • intermediate filament organization
  • hair cycle

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cornified envelope
  • cytoskeleton
  • keratin filament
  • extracellular vesicular exosome
  • basal part of cell
  • cytoplasm
  • cytosol
  • intermediate filament

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • structural constituent of cytoskeleton

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.