Tmod2 Gene Summary [Mouse]
Predicted to enable actin binding activity and tropomyosin binding activity. Acts upstream of or within learning or memory; neuron-neuron synaptic transmission; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in growth cone. Predicted to be active in striated muscle thin filament. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and notochord. Orthologous to human TMOD2 (tropomodulin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmod2 |
| Official Name | tropomodulin 2 [Source:MGI Symbol;Acc:MGI:1355335] |
| Ensembl ID | ENSMUSG00000032186 |
| Bio databases IDs | |
| Aliases | tropomodulin 2 |
| Synonyms | LOC100048637, N-TMOD, tropomodulin 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmod2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tropomodulin
- actin binding
- tropomyosin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- latent tuberculosis
- aortic valve calcification
regulates
- F Actin
role in cell
- growth
- organization
- growth in
- branching in
- synaptic transmission
- branching
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- polyribosome fractions
- dendritic spine neck
- dendritic spine head
- growth cone
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmod2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron-neuron synaptic transmission
- myofibril assembly
- pointed-end actin filament capping
- muscle contraction
- nervous system development
- actin filament organization
- positive regulation of G-protein coupled receptor protein signaling pathway
- learning or memory
Cellular Component
Where in the cell the gene product is active
- striated muscle thin filament
- cytoskeleton
- synapse
- myofibril
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- tropomyosin binding