Mettl1 Gene Summary [Mouse]
Predicted to enable internal mRNA (guanine-N7-)-methyltransferase activity and tRNA (guanine(46)-N7)-methyltransferase activity. Predicted to be involved in tRNA (guanine-N7)-methylation and tRNA stabilization. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of tRNA (m7G46) methyltransferase complex. Is expressed in articular cartilage; bone marrow; femur; long bone epiphyseal plate; and perichondrium. Orthologous to human METTL1 (methyltransferase 1, tRNA methylguanosine). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mettl1 |
| Official Name | methyltransferase like 1 [Source:MGI Symbol;Acc:MGI:1339986] |
| Ensembl ID | ENSMUSG00000006732 |
| Bio databases IDs | |
| Aliases | methyltransferase like 1 |
| Synonyms | 2810012D02RIK, C12orf1, methyltransferase 1, tRNA methylguanosine, TRM8, TRMT8, YDL201w |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mettl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA (guanine-N7-)-methyltransferase
- enzyme
- protein binding
- AdoMet_MTases
- mRNA methyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- neoplasia
- epithelial cancer
- liver cancer
- cognitive impairment
- hepatocellular carcinoma
- organismal death
- multiple sclerosis
- cholangiocarcinoma cancer
- acute myeloid leukemia
role in cell
- growth
- cell viability
- apoptosis
- expression in
- proliferation
- binding in
- differentiation
- quantity
- survival
- colony formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mettl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tRNA methylation
- tRNA modification
Cellular Component
Where in the cell the gene product is active
- tRNA methyltransferase complex
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- tRNA (guanine-N7-)-methyltransferase activity
- tRNA binding