Set Gene Summary [Mouse]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; sensory organ; skin; and tooth. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 58. Orthologous to several human genes including SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Set |
| Official Name | SET nuclear oncogene [Source:MGI Symbol;Acc:MGI:1860267] |
| Ensembl ID | ENSMUSG00000054766 |
| Bio databases IDs | |
| Aliases | SET nuclear oncogene |
| Synonyms | 2610030F17Rik, 2PP2A, 5730420M11Rik, I-2PP2A, IGAAD, IPP2A2, MRD58, PHAPII, SET nuclear oncogene, SET nuclear proto-oncogene, StF-IT-1, TAF-I, Template activating factor-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Set often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nucleosome assembly protein (NAP)
- protein phosphatase inhibitor activity
- histone binding
- PTZ00007
- nuclear localization sequence
- protein phosphatase regulator
- phosphatase
- chromatin binding
- coiled-coil domain
- protein binding
- Ran-binding domain homology domain
- acidic domain
Pathways
Biological processes and signaling networks where the Set gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- Alzheimer disease
- autosomal dominant mental retardation type 58
- epithelial cancer
- pancreatic cancer
- hereditary disorder
- organismal death
- hepatocellular carcinoma
- liver cancer
role in cell
- phosphorylation in
- degradation in
- production in
- expression in
- apoptosis
- activation in
- proliferation
- cell death
- survival
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- perinuclear region
- Endoplasmic Reticulum
- lipid droplets
- cytosol
- nucleoplasm
- neurites
- chromatin
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Set gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- DNA replication
- nucleosome disassembly
- nucleosome assembly
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- macromolecular complex
- endoplasmic reticulum
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- DNA binding
- protein binding
- histone binding
- chromatin binding
- protein phosphatase regulator activity