Mastl Gene Summary [Mouse]
Predicted to enable protein phosphatase 2A binding activity and protein serine/threonine kinase activity. Acts upstream of or within female meiosis II and positive regulation of ubiquitin protein ligase activity. Predicted to be located in centrosome; cleavage furrow; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; otic capsule; secondary oocyte; thymus primordium; and tooth. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human MASTL (microtubule associated serine/threonine kinase like). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mastl |
| Official Name | microtubule associated serine/threonine kinase-like [Source:MGI Symbol;Acc:MGI:1914371] |
| Ensembl ID | ENSMUSG00000026779 |
| Bio databases IDs | |
| Aliases | microtubule associated serine/threonine kinase-like |
| Synonyms | 2700091H24Rik, FLJ14813, GREATWALL, GW, GWL, LOC102553656, microtubule associated serine/threonine kinase-like, THC2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mastl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- protein phosphatase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- organismal death
- lung squamous cell carcinoma
- squamous cell lung cancer
- pancreatic cancer
role in cell
- expression in
- apoptosis
- proliferation
- phosphorylation in
- cell cycle progression
- growth
- cell viability
- G2 phase
- mitosis
- G2/M phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Nucleus
- centrosome
- midbody
- nucleoplasm
- spindle pole
- spindle fibers
- polar microtubule
- cleavage furrow
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mastl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- negative regulation of phosphoprotein phosphatase activity
- G2/M transition of mitotic cell cycle
- female meiosis II
- regulation of cell cycle
- peptidyl-serine phosphorylation
- response to DNA damage stimulus
- regulation of mitotic cell cycle
- mitotic cell cycle
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cleavage furrow
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein serine/threonine kinase activity
- kinase activity
- protein phosphatase 2A binding