Fignl1 Gene Summary [Mouse]
Predicted to enable ATP hydrolysis activity; magnesium ion binding activity; and microtubule severing ATPase activity. Involved in several processes, including male meiotic nuclear division; osteoblast differentiation; and osteoblast proliferation. Acts upstream of or within negative regulation of intrinsic apoptotic signaling pathway. Located in nucleus and perinuclear region of cytoplasm. Is expressed in brain ventricular layer and inferior colliculus. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human FIGNL1 (fidgetin like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fignl1 |
| Official Name | fidgetin-like 1 [Source:MGI Symbol;Acc:MGI:1890648] |
| Ensembl ID | ENSMUSG00000035455 |
| Bio databases IDs | |
| Aliases | fidgetin-like 1 |
| Synonyms | Fidgetin-Like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fignl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- ATPase family associated with various cellular activities (AAA)
- RAD51 binding domain
- enzyme
- protein binding
- hydrolase
- magnesium ion binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- schizophrenia
- MYC mutation positive B-cell lymphoma
- B cell cancer
- nonsyndromic cleft lip and palate
role in cell
- apoptosis
- proliferation
- differentiation
- cell cycle progression
- response by
- homologous recombination repair in
- meiosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fignl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male meiosis
- negative regulation of apoptotic process
- ATP metabolic process
- osteoblast proliferation
- cellular response to ionizing radiation
- osteoblast differentiation
- regulation of double-strand break repair via homologous recombination
- regulation of cell cycle
- microtubule cytoskeleton organization
- negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- cytoplasm
- nuclear chromosome
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding
- microtubule-severing ATPase activity
- hydrolase activity