Zwilch Gene Summary [Mouse]
Predicted to be involved in mitotic spindle assembly checkpoint signaling and protein localization to kinetochore. Predicted to be located in kinetochore. Predicted to be part of RZZ complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and skin. Orthologous to human ZWILCH (zwilch kinetochore protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zwilch |
| Official Name | zwilch kinetochore protein [Source:MGI Symbol;Acc:MGI:1915264] |
| Ensembl ID | ENSMUSG00000032400 |
| Bio databases IDs | |
| Aliases | zwilch kinetochore protein |
| Synonyms | 2310031L18Rik, FLJ10036, hZwilch, KNTC1AP, LOC103695356, zwilch kinetochore protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zwilch often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RZZ complex, subunit zwilch
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- adrenal cortex carcinoma
- adrenocortical carcinoma
- organismal death
- prostatic carcinoma
- prostate cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- testicular germ cell tumor
role in cell
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zwilch gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- protein localization to kinetochore
- regulation of attachment of spindle microtubules to kinetochore
Cellular Component
Where in the cell the gene product is active
- kinetochore microtubule
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding