ZWILCH Gene Summary [Human]
Involved in protein localization to kinetochore. Located in kinetochore. Part of RZZ complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZWILCH |
| Official Name | zwilch kinetochore protein [Source:HGNC Symbol;Acc:HGNC:25468] |
| Ensembl ID | ENSG00000174442 |
| Bio databases IDs | |
| Aliases | zwilch kinetochore protein |
| Synonyms | 2310031L18Rik, FLJ10036, hZwilch, KNTC1AP, LOC103695356, zwilch kinetochore protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZWILCH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RZZ complex, subunit zwilch
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- adrenal cortex carcinoma
- adrenocortical carcinoma
- organismal death
- prostatic carcinoma
- prostate cancer
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- testicular germ cell tumor
role in cell
- spindle checkpoint
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZWILCH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- protein localization to kinetochore
- regulation of attachment of spindle microtubules to kinetochore
Cellular Component
Where in the cell the gene product is active
- kinetochore microtubule
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- protein binding