Kntc1 Gene Summary [Mouse]
Predicted to enable small GTPase binding activity. Predicted to be involved in mitotic sister chromatid segregation; mitotic spindle assembly checkpoint signaling; and protein localization to kinetochore involved in kinetochore assembly. Predicted to be located in cytoskeleton; cytosol; and plasma membrane. Predicted to be part of RZZ complex. Predicted to be active in cytoplasm and kinetochore microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and spleen. Orthologous to human KNTC1 (kinetochore associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Kntc1 |
| Official Name | kinetochore associated 1 [Source:MGI Symbol;Acc:MGI:2673709] |
| Ensembl ID | ENSMUSG00000029414 |
| Bio databases IDs | |
| Aliases | kinetochore associated 1 |
| Synonyms | D330012D13, jgl, KIAA0166, KINETOCHORE ASSOCIATED 1, LOC103693647, ROD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kntc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rough deal protein C-terminal region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- colorectal cancer
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- gallbladder carcinoma
- gallbladder cancer
role in cell
- apoptosis
- survival
- alignment in
- alignment
- ceralasertib resistance
- spindle checkpoint
- mitosis
- berzosertib resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- actin cytoskeleton
- Plasma Membrane
- cytosol
- spindle pole
- kinetochore microtubule
- mitotic spindle
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kntc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- macromolecular complex assembly
- regulation of exit from mitosis
- mitotic sister chromatid segregation
- regulation of attachment of spindle microtubules to kinetochore
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- kinetochore microtubule
- spindle pole
- actin cytoskeleton
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding