Spdl1 Gene Summary [Mouse]
Predicted to enable enzyme binding activity and kinetochore binding activity. Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and protein localization to kinetochore. Predicted to be located in nucleus. Predicted to be part of outer kinetochore. Predicted to be active in spindle pole. Is expressed in several structures, including brain; gut; liver lobe; maturing glomerular tuft; and tooth. Orthologous to human SPDL1 (spindle apparatus coiled-coil protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spdl1 |
| Official Name | spindle apparatus coiled-coil protein 1 [Source:MGI Symbol;Acc:MGI:1917635] |
| Ensembl ID | ENSMUSG00000069910 |
| Bio databases IDs | |
| Aliases | spindle apparatus coiled-coil protein 1 |
| Synonyms | 1700018I02Rik, 2600001J17Rik, 2810049B11Rik, CCDC99, FLJ20364, RGD1306908, spindle apparatus coiled-coil protein 1, Spindly |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spdl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- enzyme binding
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- prostate cancer
- epithelial cancer
- lymphomagenesis
- prostatic carcinoma
- interstitial lung disease
- pulmonary fibrosis
- androgenic alopecia
- MYC mutation positive B-cell lymphoma
- B cell cancer
role in cell
- misalignment
- prometaphase
- metaphase
- scattering in
- misalignment in
- scattering
- misorientation in
- replicative senescence
- misorientation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- spindle pole
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spdl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle spindle assembly checkpoint
- cell division
- establishment of mitotic spindle orientation
- protein localization to kinetochore
- cell migration
- mitotic metaphase plate congression
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- spindle pole
- cytosol
- condensed chromosome outer kinetochore
Molecular Function
What the gene product does at the molecular level
- kinetochore binding
- protein binding
- enzyme binding