Iqcf1 Gene Summary [Mouse]
Enables calmodulin binding activity. Involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. Orthologous to human IQCF1 (IQ motif containing F1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Iqcf1 |
| Official Name | IQ motif containing F1 [Source:MGI Symbol;Acc:MGI:1921517] |
| Ensembl ID | ENSMUSG00000066383 |
| Bio databases IDs | |
| Aliases | IQ motif containing F1 |
| Synonyms | 1700055J15Rik, IQ motif containing F1, RGD1565640 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iqcf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calmodulin binding
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Iqcf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of sperm motility involved in capacitation
- positive regulation of acrosome reaction
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
Molecular Function
What the gene product does at the molecular level
- calmodulin binding