Crtap Gene Summary [Mouse]
Predicted to contribute to collagen binding activity. Involved in spermatogenesis. Acts upstream of or within peptidyl-proline hydroxylation to 3-hydroxy-L-proline. Located in endoplasmic reticulum. Is expressed in several structures, including dermis; genitourinary system; heart; rib; and stomach. Used to study osteogenesis imperfecta type 7. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 7. Orthologous to human CRTAP (cartilage associated protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crtap |
| Official Name | cartilage associated protein [Source:MGI Symbol;Acc:MGI:1891221] |
| Ensembl ID | ENSMUSG00000032431 |
| Bio databases IDs | |
| Aliases | cartilage associated protein |
| Synonyms | 5730529N23Rik, cartilage associated protein, CASP, Crtapl1, LEPREL3, LOC100653071, LOC100910835, LOC108348127, LOC253263, OI7, P3H5, RGD1565180 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Crtap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- osteogenesis imperfecta type IIB
- osteogenesis imperfecta
- growth failure
- retinal detachment
- kyphoscoliosis
- hepatitis A
- major depression
- allergic asthma
- osteoporosis
role in cell
- number
- invasion by
- signaling in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- perinuclear region
- Endoplasmic Reticulum
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Crtap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- chaperone-mediated protein folding
- peptidyl-proline hydroxylation to 3-hydroxy-L-proline
- collagen fibril organization
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- endoplasmic reticulum
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- collagen binding