Lama4 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in negative regulation of cold-induced thermogenesis. Acts upstream of or within blood vessel development and brown fat cell differentiation. Located in basement membrane. Is active in neuromuscular junction and synaptic cleft. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1JJ. Orthologous to human LAMA4 (laminin subunit alpha 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Lama4 |
| Official Name | laminin, alpha 4 [Source:MGI Symbol;Acc:MGI:109321] |
| Ensembl ID | ENSMUSG00000019846 |
| Bio databases IDs | |
| Aliases | laminin, alpha 4 |
| Synonyms | CMD1JJ, LAMA3, LAMA4*-1, LAMININ alpha 4, laminin, alpha 4, laminin subunit alpha 4, laminin subunit α 4, LAMININ α 4, laminin, α 4, RGD1560062 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lama4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- LamG
- globular domain
- PLU-1-like protein
- extracellular matrix structural constituent
- enzyme
- protein binding
- Laminin Domain II
- Tumor necrosis factor receptor superfamily (TNFRSF)
- EGF_CA
- Laminin Domain I
- Laminin-type epidermal growth factor-like domai
- Septation ring formation regulator, EzrA
- laminin G domain
- Laminin EGF domain
Pathways
Biological processes and signaling networks where the Lama4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- anemia
- bleeding
- ataxia
- pancreatic adenocarcinoma
- early missed abortion
- arrhythmia
- head and neck neoplasia
- epithelial cancer
- tremor
- fibrosis
phenotypes
- abnormal coat/hair pigmentation
- abnormal skin morphology
- corneal opacity
- decreased circulating cholesterol level
- decreased circulating insulin level
- increased heart weight
- increased spleen weight
- abnormal axon radial sorting
- abnormal blood vessel morphology
- abnormal capillary morphology
- abnormal circulating bilirubin level
- abnormal dorsal spinal root morphology
- abnormal myelin sheath morphology
- abnormal myelination
- abnormal myocardial fiber morphology
- abnormal sciatic nerve morphology
- abnormal sinus arrhythmia
- abnormal ventral spinal root morphology
- anemia
- ataxia
- cardiac hypertrophy
- cardiac interstitial fibrosis
- cardiac ischemia
- cardiomyopathy
- decreased Schwann cell number
- decreased body weight
- decreased erythrocyte cell number
- decreased heart rate
- decreased hematocrit
- decreased hemoglobin content
- decreased ventricle muscle contractility
- dilated capillary
- dilated heart left ventricle
- enlarged heart
- enlarged myocardial fiber
- heart left ventricle hypertrophy
- hemorrhage
- hypoxia
- impaired balance
- impaired basement membrane formation
- impaired limb coordination
- impaired swimming
- increased heart rate
- increased sensitivity to induced morbidity/mortality
- internal hemorrhage
- jaundice
- lethargy
- limb grasping
- myocardial fiber degeneration
- neonatal lethality incomplete penetrance
- pallor
- poor circulation
- reticulocytosis
- shortened RR interval
- tremors
role in cell
- expression in
- quantity
- number
- differentiation
- apoptosis
- proliferation
- formation
- abnormal morphology
- degeneration
- transmigration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- perisynaptic region
- neuromuscular junctions
- synapse
- sarcolemma
- extracellular matrix
- basal lamina
- axon terminals
- interphotoreceptor matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lama4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of embryonic development
- cell adhesion
- regulation of cell adhesion
- regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- extracellular region
Molecular Function
What the gene product does at the molecular level
- receptor binding
- extracellular matrix structural constituent