Nudt16 Gene Summary [Mouse]
Enables dIDP phosphatase activity and dITP diphosphatase activity. Involved in mRNA catabolic process. Acts upstream of or within chromosome organization and dITP catabolic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including gonad; heart; hemolymphoid system gland; liver; and lung. Orthologous to human NUDT16 (nudix hydrolase 16). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nudt16 |
| Official Name | nudix (nucleoside diphosphate linked moiety X)-type motif 16 [Source:MGI Symbol;Acc:MGI:1922936] |
| Ensembl ID | ENSMUSG00000032565 |
| Bio databases IDs | |
| Aliases | nudix (nucleoside diphosphate linked moiety X)-type motif 16 |
| Synonyms | 2310041H06RIK, 2810047L04Rik, 2900006H04Rik, LOC100044298, nudix hydrolase 16, RGD1311387 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nudt16 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside-diphosphatase
- metalloexopeptidase
- mRNA binding
- nucleoside-triphosphate diphosphatase
- enzyme
- magnesium ion binding
- 5' phosphomonoester producing endoribonuclease
- identical protein binding
- transition metal ion binding
- binding protein
- pyrophosphatase
- protein homodimerization
- snoRNA binding
- manganese ion binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nudt16 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cell cycle process
- snoRNA catabolic process
- negative regulation of rRNA processing
- mRNA catabolic process
- dITP catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- nucleotide binding
- dITP diphosphatase activity
- identical protein binding
- chloride ion binding
- protein homodimerization activity
- snoRNA binding
- mRNA binding
- metalloexopeptidase activity
- manganese ion binding
- cobalt ion binding