Cdc14b Gene Summary [Mouse]
Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in several processes, including positive regulation of ubiquitin protein ligase activity; protein dephosphorylation; and regulation of cell cycle process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm; nucleolus; and spindle. Is expressed in embryo. Orthologous to several human genes including CDC14B (cell division cycle 14B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc14b |
| Official Name | CDC14 cell division cycle 14B [Source:MGI Symbol;Acc:MGI:2441808] |
| Ensembl ID | ENSMUSG00000033102 |
| Bio databases IDs | |
| Aliases | CDC14 cell division cycle 14B |
| Synonyms | 2810432N10Rik, A530086E13RIK, Cdc14B1, Cdc14B2, CDC14B3, CDC14 cell division cycle 14B, cell division cycle 14B, hCDC14B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc14b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Dual specificity phosphatase, catalytic domain
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- protein-tyrosine-phoshatase
- protein serine/threonine phosphatase
- phosphatase
- protein binding
- PTP_DSP_cys
- Dual specificity protein phosphatase, N-terminal half
- Protein tyrosine phosphatase, catalytic domain motif
Pathways
Biological processes and signaling networks where the Cdc14b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- cataract disease
- insomnia
- premature aging
- kyphosis
role in cell
- expression in
- activation in
- degradation in
- growth
- G2/M phase
- stabilization in
- neural cell differentiation
- senescence
- damage in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cell junction
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc14b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- cilium morphogenesis
- regulation of exit from mitosis
- protein dephosphorylation
- microtubule cytoskeleton organization
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- cytoplasm
- spindle pole
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase activity
- protein binding
- protein tyrosine phosphatase activity
- myosin phosphatase activity