Setd3 Gene Summary [Mouse]
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein methyltransferase activity. Involved in actin modification; peptidyl-histidine methylation; and regulation of uterine smooth muscle contraction. Acts upstream of or within positive regulation of muscle cell differentiation and positive regulation of transcription by RNA polymerase II. Located in chromatin. Orthologous to human SETD3 (SET domain containing 3, actin N3(tau)-histidine methyltransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Setd3 |
| Official Name | SET domain containing 3 [Source:MGI Symbol;Acc:MGI:1289184] |
| Ensembl ID | ENSMUSG00000056770 |
| Bio databases IDs | |
| Aliases | SET domain containing 3 |
| Synonyms | 2610102I01RIK, 2610305M23Rik, 6030490B17RIK, C14orf154, D12Ertd771e, hSETD3, LOC100910833, RGD1309550, SET domain containing 3, SET domain containing 3, actin N3(tau)-histidine methyltransferase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Setd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone lysine N-methyltransferase activity (H3-K4 specific)
- transcription co-activator
- histone lysine N-methyltransferase activity (H3-K36 specific)
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription factor binding
- protein-histidine N-methyltransferase
- enzyme
- protein binding
- Rubisco LSMT substrate-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- dystocia
- hyperactive behavior
role in cell
- expression in
- quantity
- migration
- proliferation
- number
- invasion by
- differentiation
- modification
- ionizing radiation sensitivity
- methylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Setd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- regulation of uterine smooth muscle contraction
- peptidyl-histidine methylation
- peptidyl-lysine trimethylation
- peptidyl-lysine monomethylation
- positive regulation of transcription from RNA polymerase II promoter
- actin modification
- positive regulation of muscle cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- histone methyltransferase activity (H3-K4 specific)
- protein binding
- transcription coactivator activity
- actin binding
- protein-histidine N-methyltransferase activity
- histone methyltransferase activity (H3-K36 specific)
- protein-lysine N-methyltransferase activity