Eml4 Gene Summary [Mouse]
Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in mitotic spindle. Is expressed in several structures, including alimentary system; limb; liver; nervous system; and retina. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eml4 |
| Official Name | echinoderm microtubule associated protein like 4 [Source:MGI Symbol;Acc:MGI:1926048] |
| Ensembl ID | ENSMUSG00000032624 |
| Bio databases IDs | |
| Aliases | echinoderm microtubule associated protein like 4 |
| Synonyms | 4930443C24RIK, C2orf2, echinoderm microtubule associated protein like 4, ELP120, EMAP-4, EMAPL4, EMAP like 4, ROPP120 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eml4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- WD40 repeats
- TD_EMAP-like
- alpha-tubulin binding
- HELP motif
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- narcolepsy type 1
- prostate cancer
- infantile hypertrophic pyloric stenosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- insomnia
- chronic obstructive pulmonary disease
role in cell
- growth
- phosphorylation in
- proliferation
- attachment
- depolymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- cilia
- microtubules
- midbody
- cytoplasmic bridges
- microtubule organizing centers
- cytosol
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eml4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- attachment of spindle microtubules to kinetochore
- microtubule cytoskeleton organization
- mitotic metaphase plate congression
- mitotic cell cycle
- microtubule-based process
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- microtubule organizing center
- mitotic spindle
- cytoplasm
- membrane
- cytosol
- midbody
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-tubulin binding
- alpha-tubulin binding
- microtubule binding