Gpbp1 Gene Summary [Mouse]
Enables DNA binding activity and DNA-binding transcription factor activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human GPBP1 (GC-rich promoter binding protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpbp1 |
| Official Name | GC-rich promoter binding protein 1 [Source:MGI Symbol;Acc:MGI:1920524] |
| Ensembl ID | ENSMUSG00000032745 |
| Bio databases IDs | |
| Aliases | GC-rich promoter binding protein 1 |
| Synonyms | 1700034P14RIK, D230035M11RIK, GC-rich promoter binding protein 1, GPBP, mGPBP, RGD1305492, SSH6, VASCULIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Vascular protein family Vasculin-like 1
- protein binding
- transcription factor activity
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Plasma Membrane
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription, DNA-dependent
- regulation of transcription, DNA-dependent
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA binding