Rspo4 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within nail development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo ectoderm; limb; lower urogenital tract; tooth; and urethra of male. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 4. Orthologous to human RSPO4 (R-spondin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rspo4 |
| Official Name | R-spondin 4 [Source:MGI Symbol;Acc:MGI:1924467] |
| Ensembl ID | ENSMUSG00000032852 |
| Bio databases IDs | |
| Aliases | R-spondin 4 |
| Synonyms | A730099F22, A930029K19Rik, C20orf182, CRISTIN4, RGD1563415, R-spondin 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rspo4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FU
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rspo4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- nail development
- Wnt receptor signaling pathway
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- heparin binding