Usp20 Gene Summary [Mouse]
Predicted to enable G protein-coupled receptor binding activity; cysteine-type deubiquitinase activity; and cysteine-type endopeptidase activity. Predicted to be involved in several processes, including antiviral innate immune response; protein deubiquitination; and regulation of signal transduction. Predicted to be located in centrosome. Is expressed in ganglia; retina; and trigeminal nerve. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp20 |
| Official Name | ubiquitin specific peptidase 20 [Source:MGI Symbol;Acc:MGI:1921520] |
| Ensembl ID | ENSMUSG00000026854 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 20 |
| Synonyms | 1700055M05Rik, hVDU2, LSFR3A, ubiquitin specific peptidase 20, VDU2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- Zn-finger in ubiquitin-hydrolases and other protein
- peptidase
- G-protein-coupled receptor binding
- Ubiquitin carboxyl-terminal hydrolase
- ubiquitin-specific protease
- DUSP domain
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- protein binding
- ubiquitin C-terminal hydrolase domain
- Peptidase_C19
Pathways
Biological processes and signaling networks where the Usp20 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- hepatocellular carcinoma
- epithelial cancer
- neoplasia
- liver cancer
- atherosclerosis
- hyperplasia
- neonatal late-onset sepsis
- connective tissue neoplasm
- organismal death
role in cell
- expression in
- phosphorylation in
- activation in
- migration
- proliferation
- degradation in
- binding in
- colony survival
- invasion by
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- perinuclear region
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- positive regulation of autophagy
- proteolysis
- negative regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of G-protein coupled receptor protein signaling pathway
- endocytosis
- protein K48-linked deubiquitination
- protein K63-linked deubiquitination
Cellular Component
Where in the cell the gene product is active
- centrosome
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- G-protein coupled receptor binding
- zinc ion binding
- protein binding
- cysteine-type endopeptidase activity