Hsf4 Gene Summary [Mouse]
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and protein phosphatase binding activity. Predicted to be involved in lens fiber cell differentiation and negative regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and nuclear speck. Is expressed in several structures, including brain; lens; respiratory system; submandibular gland; and urinary system. Used to study cataract 5 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Orthologous to human HSF4 (heat shock transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Hsf4 |
| Official Name | heat shock transcription factor 4 [Source:MGI Symbol;Acc:MGI:1347058] |
| Ensembl ID | ENSMUSG00000033249 |
| Bio databases IDs | |
| Aliases | heat shock transcription factor 4 |
| Synonyms | CTM, CTRCT5, heat shock transcription factor 4, HSTF 4, ldis1, mHSF4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hsf4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HSF-type DNA-binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- protein phosphatase binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital zonular cataract
- lamellar cataract 5
- cataract disease
- multiple types cataract 5
- Down syndrome
- Waldenström macroglobulinemia
- congenital cataract
role in cell
- cell viability
- proliferation
- replication in
- differentiation
- development
- abnormal morphology
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hsf4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- lens fiber cell differentiation
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity