Numa1 Gene Summary [Mouse]
Predicted to enable several functions, including disordered domain specific binding activity; dynein complex binding activity; and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; positive regulation of BMP signaling pathway; and positive regulation of keratinocyte differentiation. Located in lateral cell cortex; mitotic spindle pole; and nuclear matrix. Is expressed in several structures, including 1st branchial arch mandibular component; early embryo; facial prominence; oocyte; and telencephalon. Orthologous to human NUMA1 (nuclear mitotic apparatus protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Numa1 |
| Official Name | nuclear mitotic apparatus protein 1 [Source:MGI Symbol;Acc:MGI:2443665] |
| Ensembl ID | ENSMUSG00000066306 |
| Bio databases IDs | |
| Aliases | nuclear mitotic apparatus protein 1 |
| Synonyms | 41/7 NMP, 6720401E04Rik, AL022610, AU014979, NMP-22, NMP 41/7, NUCLEAR MATRIX ANTIGEN, nuclear mitotic apparatus protein 1, NUMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Numa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Hook domain-containing proteins superfamily
- spindle association domain
- Synaptonemal complex protein 1 (SCP-1)
- helix-rich Mycoplasma protein
- coiled-coil domain
- chromosome segregation protein SMC, common bacterial type
- Lgn binding domain
- ligand-binding domain
- tubulin binding
- tail domain
- HOOK protein coiled-coil region
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- Rabaptin-like protein
- exonuclease SbcC
- DNA binding domain
- rad50
- nuclear localization sequence
- Myosin tail
- protein domain specific binding
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- phosphatidylinositol binding
- RecF/RecN/SMC N terminal domain
- microtubule binding
- binding protein
- tankyrase binding domain
- microtubule plus-end binding
- structural molecule
Pathways
Biological processes and signaling networks where the Numa1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- renal cell cancer
- microalbuminuria
- diabetic ketoacidosis
- preeclampsia
- renal cell carcinoma
role in cell
- proliferation
- quantity
- growth
- cell viability
- formation
- stabilization
- organization
- differentiation
- assembly
- endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- microtubule aster fraction
- spindle apparatus
- Cytoplasm
- cell cortex
- Plasma Membrane
- spindle pole bodies
- centrosome
- microtubules
- microtubule bundles
- cytosol
- interchromatin space
- nucleoplasm
- nucleoli
- spindle pole
- spindle fibers
- nuclear matrix
- cytoplasmic microtubule
- astral microtubules
- central spindle
- mitotic spindle
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Numa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- regulation of metaphase plate congression
- nucleus organization
- regulation of mitotic spindle organization
- cell division
- establishment of mitotic spindle orientation
- positive regulation of BMP signaling pathway
- astral microtubule organization
- positive regulation of chromosome segregation
- meiotic cell cycle
- microtubule bundle formation
- positive regulation of intracellular transport
- anastral spindle assembly
- positive regulation of microtubule polymerization
- positive regulation of hair follicle development
Cellular Component
Where in the cell the gene product is active
- lateral plasma membrane
- microtubule plus end
- spindle pole
- neuronal cell body
- chromosome
- plasma membrane
- nucleoplasm
- spindle microtubule
- spindle pole centrosome
- dendrite
- nucleus
- centrosome
- extracellular vesicular exosome
- mitotic spindle
- cell cortex
- spindle
- cytosol
- nuclear matrix
- macromolecular complex
- cortical microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein domain specific binding
- protein binding
- microtubule minus-end binding
- microtubule plus-end binding
- phosphatidylinositol binding
- structural molecule activity
- dynein complex binding
- microtubule binding