ARHGAP44 Gene Summary [Human]
Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ARHGAP44 |
| Official Name | Rho GTPase activating protein 44 [Source:HGNC Symbol;Acc:HGNC:29096] |
| Ensembl ID | ENSG00000006740 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 44 |
| Synonyms | 6330543G20, KIAA0672, NPC-A-10, RGD1305664, Rho GTPase activating protein 44, RICH-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- phospholipid binding
- enzyme binding
- GTPase activator
- BAR domain
- protein binding
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- Bin/Amphiphysin/Rvs domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- cleft lip
- organismal death
- multiple system atrophy
- osteosarcoma
- osteosarcomagenesis
role in cell
- apoptosis
- binding in
- expression in
- binding
- migration
- invasion by
- proliferation
- quantity
- assembly
- loss in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- postsynaptic region
- cytosol
- dendritic spines
- synapse
- cell membrane leading edge
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of dendritic spine morphogenesis
- regulation of actin cytoskeleton organization
- signal transduction
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- negative regulation of Rac protein signal transduction
- regulation of synaptic transmission
- negative regulation of filopodium assembly
- exocytosis
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- presynaptic active zone
- dendritic spine
- cytosol
- leading edge membrane
- recycling endosome
- intracellular
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity
- small GTPase binding
- phospholipid binding