Bst2 Gene Summary [Mouse]
Predicted to enable metalloendopeptidase inhibitor activity and protein homodimerization activity. Involved in several processes, including negative regulation of intracellular transport of viral material; negative regulation of viral genome replication; and response to type II interferon. Located in cell surface. Is expressed in cerebral cortex and retina. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and endometrial cancer. Orthologous to human BST2 (bone marrow stromal cell antigen 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bst2 |
| Official Name | bone marrow stromal cell antigen 2 [Source:MGI Symbol;Acc:MGI:1916800] |
| Ensembl ID | ENSMUSG00000046718 |
| Bio databases IDs | |
| Aliases | bone marrow stromal cell antigen 2 |
| Synonyms | 120g8, 2310015I10RIK, bone marrow stromal cell antigen 2, CD317, DAMP-1, GREG, HM1.24, LOC100129681, Pdca-1, TETHERIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bst2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- coiled-coil domain
- protein binding
- Bone marrow stromal antigen 2
- identical protein binding
- endocytic domain
- cytoplasmic domain
- ubiquitination site
- transmembrane domain
- protein homodimerization
- cytosolic tail domain
- GPI anchor
- metalloendopeptidase inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- hematological neoplasia
- systemic lupus erythematosus
- acute myeloid leukemia
- endometriosis
- Sjogren syndrome keratoconjunctivitis sicca
role in cell
- phosphorylation in
- degradation in
- production in
- expression in
- apoptosis
- activation in
- proliferation
- cell death
- growth
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- caveosome
- intracellular membrane-bounded organelle
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- perinuclear region
- cellular membrane
- endosomes
- Golgi Apparatus
- secretory granule membrane
- apical cell surfaces
- apical membrane
- trans Golgi network
- cis Golgi networks
- lysosome membrane
- recycling endosomes
- multivesicular bodies
- membrane rafts
- microvilli
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bst2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to interferon-gamma
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- B cell activation
- response to virus
- regulation of actin cytoskeleton organization
- negative regulation of cell growth
- innate immune response
- negative regulation of plasmacytoid dendritic cell cytokine production
- positive regulation of leukocyte proliferation
- defense response to virus
- response to interferon-alpha
- response to interferon-beta
- negative regulation of viral genome replication
- negative regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- membrane raft
- Golgi apparatus
- multivesicular body
- azurophil granule membrane
- apical plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- RNA binding
- metalloendopeptidase inhibitor activity