Ifitm3 Gene Summary [Mouse]
Involved in host-mediated suppression of symbiont invasion and response to virus. Acts upstream of or within defense response to other organism; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including egg cylinder; embryo ectoderm; genitourinary system; gut; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifitm3 |
| Official Name | interferon induced transmembrane protein 3 [Source:MGI Symbol;Acc:MGI:1913391] |
| Ensembl ID | ENSMUSG00000025492 |
| Bio databases IDs | |
| Aliases | interferon induced transmembrane protein 3 |
| Synonyms | 1110004C05Rik, Cd225, Cdw217, DSPA2b, Fgls, Ifm3, Interferon beta induced, Interferon induced, interferon induced transmembrane protein 3, Interferon inducible, Interferon β induced, IP15, mil-1, rat8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifitm3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Interferon-induced transmembrane protein
Pathways
Biological processes and signaling networks where the Ifitm3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- infection
- experimentally-induced diabetes
- adenoma formation
- pituitary gland adenoma
- head and neck neuroendocrine neoplasia
- experimental autoimmune encephalomyelitis
- infection by severe acute respiratory syndrome coronavirus 2
- infection by Listeria monocytogenes
role in cell
- expression in
- invasion by
- proliferation
- killing
- development
- infiltration by
- bacterial load
- degradation in
- deposition
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cell-cell contacts
- lysosome membrane
- endosomal membrane
- cytoplasmic vesicles
- microsomal membrane