Tpst1 Gene Summary [Mouse]
Enables protein-tyrosine sulfotransferase activity. Involved in peptidyl-tyrosine sulfation and post-translational protein modification. Is active in Golgi lumen and trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human TPST1 (tyrosylprotein sulfotransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpst1 |
| Official Name | protein-tyrosine sulfotransferase 1 [Source:MGI Symbol;Acc:MGI:1298231] |
| Ensembl ID | ENSMUSG00000034118 |
| Bio databases IDs | |
| Aliases | protein-tyrosine sulfotransferase 1 |
| Synonyms | protein-tyrosine sulfotransferase 1, protein-tyrosine sulphotransferase 1, TANGO13A, tyrosylprotein sulfotransferase 1, tyrosylprotein sulphotransferase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein homodimerization
- enzyme
- protein-tyrosine sulfotransferase
- Sulfotransferase family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- gout
- metabolic syndrome X
role in cell
- tyrosine sulfation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi lumen
- cellular membrane
- Golgi membrane
- trans Golgi network
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
- post-translational protein modification
- peptidyl-tyrosine sulfation
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein-tyrosine sulfotransferase activity